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广州市康莉生物科技有限公司 Mori Bio-Tech (Guangzhou) Ltd.
Brief Introduction to the Company MoriBio-Tech (Guangzhou)Ltd. is a professional company involved in the application, research,manufacturing and marketing of natural vegetative tonic products. The companyowns four major mulberry fruit planting bases, which thousands acres ofupgraded mulberry trees. Its operations includes tourism, agriculturalplanting, drink production etc.. The company’s offices are settled in the What is so tonic aboutmulberry
There hasbeen a thousand-year history of mulberry planting in
AnIntroduction to the Mori Mulberry Leaf Tonic Tea —— A New Generation of Anti-DiabetesNatural Vegetative Tea Product Part One: What is the Mori Tea’s material-mulberry leaf ? Mulberry Leaf Source:The leaf of Morus alba L.. Collecting and Processing: It’s collected after the first frost,removed of the impurity, and insolated. Chemical Ingredient: It contains inokosterone, ecdysterone , β- sterols, rutin, morocetin, iso-daimyo-oak-skin glucoside, umbelliferone, scopolin, α-，β-hexenal, trigonelline, choline, adenine, aspartic acid, sodium acid. Part Two: An approach to thenutrition value and high blood sugar lowering effect of mulberry leaf. Mulberryleaf, i.e. Morus.al-ba.L., has already been applied for long, in both dietaryand medical uses broadly among the people. From of old, herbalist doctors have been adopting mulberry leaf as akind of Chinese traditional medicine in clinics, curing the Xiaoke Zheng(as inmodern iatrology, the diabetes). As stated in ‘the Compendium of Material Medic’, mulberry leaf ‘can be decocted and itsjuice can be a substitute of tea, which can heal diabetes’ ; ‘Bake it or decoct it, anddrink it to cease the thirst, just like tea.’ Doctors of modern times also included mulberry leaf in some Chinesetraditional medicine compounds often for clinic application. And it has beenfrequently proved of its availability.
The proof by modern pharmacology study: Mulberry leaf is able to restrain the raisingof blood sugar level and prevent and cure diabetes. In recent years, throughsystematic researches on the composition, function, and mechanism of mulberryleaf by researchers from all countries, it is discovered that abundant aminoacid, cellulose, vitamin, mineral substance, and various physiological activesubstance are contained in mulberry leaf. And they have tonic efficacy oflowering blood sugar, lowering blood pressure, lowering blood fats, and prolonginglife, etc..
1. The nourishmentvalue of mulberry leaf As has beendiscovered by researchers of the Research Institute of Functional Foods in Kanagawa Countyin Form 1：VariousNutrition Components and their Content in Mulberry Leaf
Form 2：The Tonic Efficacy ofMulberry Leaf and Relevant Physiological Active Substances and Their Contents
2．Theblood sugar-lowering active ingredients in mulberry leaf As isproved by research materials home and abroad, alkaloid and polyose are the main blood sugar-lowering active substances in mulberry. Asano and other scientists have asundered 6kinds of alkaloid from mulberry: 1-DNJ, N-Me-DNJ, GAL-DNJ, fagomine, DAB andCalystegin B2, and they have confirmed their molecular structure. Kimura hasstudied the 6 kinds of compounds’ blood sugar-lowering effects on mousesuffering diabetes caused by Streptozotocin(STZ). Experiment result indicatedthat, N-Me-DNJ、GAL-DNJ、fagomine can allsignificantly detract blood sugar level, among which the blood sugar lowering efficacy of GAL-DNJ andfagomine is the most evident. After usingtotal polyose of mulberry (TPM) inthe visceral injection on alloxandiabetes rat, the result indicated that TPM takes significanteffect of blood sugar-lowering. But TPM’s structure needs to be furtherstudied. There has been some researches oneffective ingredients of a tonic product mainly composed of mulberry, theoutcome showed that both polyose andalkaloid significantly reduce the fasting blood glucose in a alloxan diabetesmouse，and they also evidently prevent any increase of blood sugar in themouse. 3．The functional mechanism of mulberry By far people have been focusing on two aspects of the functional mechanism of mulberry: one is fromthe restraining influence that mulberry ingredients have on disaccharide clastic enzyme activity; the other is from the enforcementto the pancreatic island ß cell excretion of insulin by mulberry ingredients. Form 3 is a summaryof development in the research on mulberry’s blood sugar-lowering effectsrecently. Form 3：Functionalmechanism of mulberry’s blood sugar-lowering and relevant researches
Studiesshow that there are two was in which mulberry lowers blood sugar: one,restraining activity of disaccharideclastic enzyme with mulberry alkaloid DNJ, thus restraining the small intestine’s absorbing of diose, and reducing the blood sugar peak value after meal; two, mulberryalkaloid fagomine and mulberry amylose boost ß cells to excrete insulin,which promotes cell’s adoption of sugar, synthesis of glycogen, and improvessugar metabolism, and it ultimately achieves the effect of sugar bloodlowering. The authorhas conducted a research on a blood sugar lowering tonic product mainlycomposed of mulberry, in cooperation with Physiology Department, Xiangya MedicalSchool, Mid-South University. In observation over its prevention and“healing” effect on mouse’s diabetes caused by alloxan, the result showed that: 1、Prevention：Productand its separated groups in alkaloid and amylose, they are poured into themouse’s stomach with a body weight dose of0.4ml/20g each, the prevention is on the increase of mouse’s blood sugar causedby alloxan. 3 days after the alloxan injection, the alkaloid group and alkaloid+amylose +flavonegroup’s blood sugar level is evidently lower than comparative group, which maybe related to the fact that alkaloid can reduce the blood sugar increasingsevere reaction caused by alloxan.（p<0.01）；7 days after the alloxaninjection, the product undiluted liquid group’s animal blood sugarconcentration falls to the level before the alloxan injection. The differenceis very evident with the comparative group，and alkaloid and amylosegroup sugar blood level is evidently lower than comparative group（p<0.05）. 2、Treatment：the product undiluted liquid and its effective ingredients alkaloidand amylose are poured into a alloxan high bloodsugar mouse’s stomach with a body weight dose of 0.4ml/20g each for 7days, and this can bring down the high blood sugar mouse’s fasting blood sugar, which proves the efficacy of product undilutedliquid is better than phenethyl diguanide. Before taking theproduct all animal’s fasting blood sugarevidently raises, higher than normal mouse, the model is successfully built. Given the product undiluted liquid for 3 days, the concentration of bloodsugar evidently falls, compared withbefore taking and homochronous distilled water group, the discrepancy makessignificant sense <0.01）；7 days after stomach pouring, phenethyl diguanide group animal’s fasting blood sugar falls obviouslycompared to before and homochronous distilled water group, the discrepancymakes statistics sense（P<0.01）；undiluted liquid blood sugar evidently falls, the discrepancy makessignificant sense（P<0.01）；alkaloidand amylose group blood sugar also falls, the discrepancy makes statistics sense（P<0.05），but the effect is weaker than undiluted liquid and phenethyl diguanide. The experiment continues to validate the blood sugar lowering function ofalkaloid and amylose. The results also show that mulberry amylose, alkaloid andother ingredients in product act out some concerted and compatible effects.Combining the falconoid and mulberry DNJ, addingit to drink, this kind of drink restrains more effectively the rise of bloodsugar than mulberry DNJ alone, which means falconoid and mulberry DNJ have some concerted effect. But itsconcerted mechanism still needs to be studied further. Though there is no research report on the influence from mulberry speciesand producing area on the effective contents, but it has been proved byrelevant study, that mulberry effective content has much to do with vegetative period. That is, early autumn and after frost are the timeswhen the flavone and polyphenol content raises obviously. Besides, theabstraction temperature has large influence on mulberry effective ingredients:mulberry is often abstracted in high by high temperature, which does not onlyimpact some effective components, and also cause the bitterness of extraction. Throughrepetitive experiments by the author, it is discovered that the method ofladder temperature (i.e., use different temperature for different effectivecomponents) can effectively abstract different effective components, and keepthe extract’s great taste. 4．The human body clinic application of mulberry blood sugarlowering By now， there are 130 million of diabetes patients across theglobe, and number is still on a radical rise. Its main causes are surfeit,Occidentalize of dietary life, deficiency of exercise, obesity and stressreaction. There is no symptom at the beginning of diabetes, but what’s to befeared is that if it’s ignored when hard to be noticed, there can be kidneydamage, diseases of retina, nervouslesion diabetes complication or something fatal like miocardial infarction,cerebral thrombosis. To avoid such situation, proper dietary habits andstrengthened exercise are required. Therefore, as a natural non-poisonousfood/medicine, mulberry is drawing increasing attentions. Here is a clinic experiment for 24 male diabetes patients ranged from 40-60years old, these 24 patients are divided into two groups randomly and equally.One of them take hypoglycemic drugglibenclamide capsule（5mg/d），the othertakes mulberry powder capsule, the time of drug using is 30 days. 30 days laterpatients’ plasma and urine are brought to the test. As is shown in the result,compared with hypoglycemic drugglibenclamide capsule, mulberry capsule has evident blood sugar loweringeffect, the reduction rate is 27%（P<0.01）. Meanwhile, the cholesterol content in the blood also falls by 12%（P<0.01）. In cooperation with Natural Plant Application/Research Center of SouthMedical University (formerly the First Military Medical University), the authorcarried out a study on a blood sugar lowering tonic product mainly composed ofmulberry, observing its clinic efficacy. The result is: 20ml/person/day，using for 3 months in a row， 3 months later, according to the fasting blood drawing from the users, the total effective rate is 94.74%，andevident effective rate is 50.88%（patient’s blood sugarlevel falls back to normal）. 5. Mulberry bloodsugar lowering mechanism summary Though themechanism of how mulberry adjusts blood sugar has not yet been very clear, withthe development and report from modern researches about blood sugar adjustment,we anticipate in the following way mulberry lowers blood sugar.
6.Theresearch prospect and outlook Numerous researches on mulberry blood lowering function has provedadequately the efficacy of mulberry. And studies on the mechanism of mulberryconvey that mulberry amylose and alkaloid are the major effective components,they lower the blood sugar by restrainingα-glycosidase and boosting excretion of B cell insulin. And therehas been lots of experiments that proved certain compatibility and abstractionmethods are needed, also a proper scale of dosage, in order to perfect bloodsugar lowering function of mulberry. And that explains why mulberry has beenfor medical use since long ago but never been used to cure diabetes. Modernscientists make further study and understanding on mulberry, thus its bloodsugar lowering tonic function is gradually known by the public and givenimportance. Mulberry isa product for both food and medicine approve by national ministry of health. It has security, but no side effects. As peoplestudy and know more about mulberry, blood sugar lowering tonic food is going tobe a remarkable prevention food against high blood sugar and diabetes. However,the composition and molecular structure of mulberry amylose, the mechanism ofhow mulberry amylose and alkaloid boost insulin excretion, and how othercomponents are concerted in this function, these subjects are yet to bediscussed and researched. Part 3: How is Mori Tonic Tea produced? Mori Mulberry Tonic Tea is made from rawmaterial of 100% natural mulberry,the mulberry leaves has been through processofrinsing, draining, enzyme eliminating, desiccating, disintegrating, screening and then into tealeaves, very convenient for drinking and carrying. The leaves color is brownand green, the soup color is green and yellow, sweet and freshing, mellow andlasting。 Summary：Major effects on human body by Mori MulberryTonic Tea Its efficacies include cooling andthirst assuaging, appetitestimulating, colds preventing.And against colds,headaches and coughing, red eye that’sore and swollen it has certain effects. 1、 It prevents diabetes, andthrough restraining α-glycosidesenzyme and boosting B cells excretion of insulin it effectively reduce highsugar symptoms. 2、 It effects as eliminating dampnessthrough diuresis. Eliminating dampness through diuresis is different fromincreasing the discharge of urine.It does not only increase the discharge of urine, but also eliminate theredundant water inside the cells. Therefore, mulberry tea can cure theso-called oedema. 3、 Purifying the blood means discharging theexcessive neutral fats and cholesterol in the blood. Neutral fats and cholesterol in the bloodexcessively increase will cause hyperlipoemia. So the weight – watchers are mostly hyperlipoemia patients. 4、 Losing weightand removing fats：Mulberryleaves contains flavones content that can strengthen capillarytube, reduce the blood viscosity. It can eliminate the redundant neutral fats and cholesterol in the blood,thus to achieve losing weight and solve high blood lipid. 5、 The mulberry tea is a kind oflow heat and nourishing food. It has no limits，for young and old, and for all seasons。
Mori juice Mulberry Fruit [quality] sweet、sour、warm
[function of efficacy]：Mulberry isalso called mulberry fruit, mulberry jujube. From of old, mulberry hasalways been used as a kind of fruit and traditional medicine. And now it hasbeen classified by the Sanitation Department of China as one of the farmproduces ‘that can either be food or medicine‘ Mulberry fruit does not onlytaste great, it also boasts various tonic functions, which was stated in mostof famous Chinese traditional books. The following is for reference.
The proof from modern iatrology： According to relevant information, the components ofmulberry fruit is:85％ ofwater，5－13％ of sugar, which is mainly dextrose and fructose， 4.8－8.2％ of variousvitamin，in which VC takes up the most, and then VB1,VB2, and total acidity is between 0.11－0.25％，varying largely between different species. Though it’s not asbright-colored and attractive as large-scale fruit like apple, pear, and peach,but mulberry’s nutrition and tonic value is rather high, and its vitamin andniacin content is several times higher than that of apple. Recently a research by Professor Sinclay from Harvard University showed that resveratrolinside mulberry plays a key role in fighting agaist senium.Resveratrol is an vital kind of phytoalexin and antioxidant. It can take on anti oxygenation against freeradicals generated from lipids peroxidation inside cellular NADPH,Fe－microsome andfrom cellular endogenesis. It can eliminate and quench active oxygen mediums fromcellular oxidation stress. The resveratrolcan resist the damage against DNA by active oxygen mediums, and it can preventlipids peroxidation of the cytolemma. It is alsoanti – inflammatory, antianaphylaxisand anti-mutagenesis. Meanwhile resveratrol has an influenceon lipids and arachidonic acid metabolism，and it also prevents the oxidation of low-density lipoproteins， platelet aggregation， thus it keeps the body young and healthy, not easy toget tired orsick. And it has special efficacy against senium and its relevant diseases suchas tumour, neural reversion, mental disorders, heart disease and atherosclerosis.
The benefits mulberry fruit can make formodernurbanites：
1、Preventing angiosclerosis. Mulberry fruit containsabundant fatty acid, which mainly consists of linoleicacid,stearic acid and oleic acid. It acts out functions such as decomposingredundant fats, lowering blood lipid，and preventing angiosclerosis. 2、Mulberry fruitcontains nutritive substances like tannic acid，fatty acid, malic acid，thus it helps thedigestion of fat, protein and amylum. Therefore it has the benefits of strengtheningthe spleen and stomach, aiding digestion，and it can also heal diarrhea causedby indigestion. 3、Mulberry contains 18kinds of essential amino acids for human body, 7 kinds of vitamins and variousmineral substances and carbohydrate carotene and human microelements. It caneffectively supply nutrition needed body, and its tonic but not too muchcalory. Thus it’s suitable for dietary treatment of hypertension patients. 4、Mulberry does notonly contains large amount of essential nutrition substances, it also containshair blackener, which can make your hair black and shiny, thus it’s also for beautification。 5、The rutin， anthocyan， dextrose， fructose， malic acid，calcium substances，inorganic salts, various vitamins and nicotinic acidin mulberry fruit, all has a efficacy of preventing the diffusion of tumorcells and theoccurrence cancer. 6、 The special substances in mulberryfruit is capable of looseing the bowel to relieve constipation. Therefore it can make the elimination oftoxicant and beautification. 7、Thanks to the resveratrolcontained in mulberry，it can help you body fight against senium.
How is Mori Syrup made? Mori Syrup is a product of research and supervision by thecombination of U.S. Mori International Corporation and the Agricultural ScienceInstitute of China. During itsproduction, improved refrigerationequipments and packing equipments are introduced, so are the subzero 30℃ low temperature technology, therefore, the fresh keeping problem issolved and the activity and flavor of mulberry’s effective ingredients arereserved. Meanwhile we apply vacuum bottling technics, which turns 100%pure and fresh mulberry fruit juice into pure and fresh concentrated mulberryfruit drinks that you can keep for over one year. A Report on the Mori Syrup and aSummary Chemical ingredients of the MoriMulberry Syrup Nutriologicallyspeaking, the major nutrition value of a fruit lies in the tonic functions ofvitamins and mineral substances, which are hard to be replaced by flesh andgrist. The main composing ingredients of mulberry fruit are entailed in form 1,3. : Form 1 basic ingredients of mulberryfruit
Form 2 main ingredients pf Mori Syrup(compared with apple juice)
Form 3 vitaminand mineral substance content of mulberry fruit (mg/L) (compared with applejuice)
As we can see in form 1, syrup takes uppredominant portion in mulberry fruit. As we can see in form 2 and form 3,though soluble solid material content in the mulberry juice is relatively low,it contains abundant organic acids, vitamins, and mineral substances.Compared with apple juice, the content of protein and fats in the mulberryfruit juice is relatively higher, so is the content of vitamin B1, B2, folicacid, nicorinic acid, and that ofkalium，iron, calcium and phosphor. Amongthat the content of iron is over 10 times as much as in apple juice, and thecontent of kalium1.4 times. Iron is one of the essential microelements for human body, and oneof the important components of hematoglobulin,myoglobin, etc.. Irondeficiency causes diseases like anaemia and so on. Kalium is a kind of important element that maintainsnormal cardiac rhythm, andenhances muscle excitation. It can remedy the weakening of the vessel's wallcaused by arteriosclerosis, and also prevents arteriosclerosis. Form 4 thefree amino acids content in mulberry syrup (mg/100ml)
As is shownin form 4, abundant free amino acids are containedin mulberry syrup, including all 10 kinds of essential amino acids and 10 kindsof essential amino acids for human body. Therefore if youdrink certain amount of mulberry syrup everyday, you can enjoy efficientsupplement of various vitamins, mineral substances, and amino acids that are essential for human body, and also the acid alkalibalance in vivo.
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